Feeling nauseated after your Spravato® (esketamine) treatment can be unpleasant — but it’s also common, temporary, and manageable. Mild nausea is one of the most frequently reported side effects of Spravato®, and most patients find it improves within hours or with a few simple adjustments.
At Blue Water Psychiatry, our experienced clinicians guide patients through every step of Spravato® therapy — from preparation to recovery. We’ve gathered these clinically tested, real-world tips to help you minimize nausea and feel more comfortable during your treatment journey.
Why Spravato® Can Cause Nausea
Spravato® is a nasal spray form of esketamine, a medication that acts on brain receptors involved in mood regulation and neural growth. Because it also temporarily affects balance, blood pressure, and perception, some patients experience mild nausea, dizziness, or a “floating” sensation.
These effects:
- Usually begin within minutes of dosing
- Peak during the 40–60 minutes after administration
- Subside naturally by the end of your two-hour monitoring period
While nausea is usually mild, preparation and aftercare make a big difference in comfort and overall treatment experience.
Before Your Spravato® Session: Preventive Strategies
- Avoid heavy meals for 2–3 hours before treatment
A full stomach can worsen nausea, while an empty one may cause dizziness. Try a light snack, such as crackers, toast, or fruit, about an hour before your appointment. - Stay hydrated — but sip, don’t chug
Dehydration can make nausea more intense. Drink water steadily throughout the day, but avoid large amounts immediately before dosing. - Discuss preventive medications with your provider
Your clinician may recommend taking an anti-nausea medication (such as ondansetron/Zofran) about 30 minutes before treatment if you’ve experienced nausea in previous sessions. - Skip caffeine before dosing
Coffee and energy drinks can raise heart rate and amplify jitteriness or queasiness. Opt for herbal tea or water instead. - Dress comfortably and rest well
Tiredness or tight clothing can heighten discomfort. Arrive relaxed, in comfortable attire, and well-rested for your session.
During Your Spravato® Treatment
- Recline and relax
Once you’ve self-administered the nasal spray, rest comfortably in the reclined chair provided. Close your eyes or focus softly on one point in the room. - Breathe slowly and steadily
Deep, rhythmic breathing helps regulate your nervous system and minimizes sensations of nausea. - Use grounding or distraction techniques
Gentle background music, guided imagery, or focusing on your breathing pattern can redirect attention away from discomfort. - Communicate with your provider
Our team monitors you closely throughout the session. If nausea develops, let us know — we can offer anti-nausea medication or adjust your position to help you feel better.
After Your Appointment: Recovery Tips
- Take it slow
Nausea typically fades within one to two hours after your session. Move slowly when standing, and avoid sudden head movements. - Eat light and bland foods
Once you feel ready, start with simple foods like crackers, rice, bananas, or soup. Avoid spicy or greasy meals until your stomach feels settled. - Rest and hydrate
Spend the rest of the day in a calm environment, drinking water or electrolyte beverages. Avoid alcohol or caffeine until the next day. - Note patterns
Keep track of when nausea occurs and how long it lasts. This helps your provider fine-tune your pre-treatment plan or dosing schedule. - Give your body grace
It’s common to feel fatigued or mildly off-balance after Spravato®. These sensations usually fade by the following day — and most patients notice improvement with each subsequent session.
When to Contact Your Provider
Call your provider if you experience:
- Severe or prolonged nausea lasting more than 24 hours
- Vomiting or inability to keep fluids down
- Worsening dizziness or confusion
Our team at Blue Water Psychiatry is always available to review your symptoms and make adjustments to your next treatment plan for a smoother experience.
Why Arizona Patients Choose Blue Water Psychiatry for Spravato®
- Certified Spravato® treatment center with on-site medical supervision
- Board-certified psychiatric providers experienced in depression and anxiety care
- Comfortable, private treatment suites with supportive staff monitoring every step
- Personalized care — including anti-nausea and relaxation support options
- Flexible scheduling for working adults and families
- Same-week availability for new patient evaluations
- Locally trusted and highly rated across Mesa, Gilbert, Chandler, and the Phoenix Valley
We make Spravato® treatment comfortable, personalized, and centered on your well-being.
Feel Better, More Comfortably
Mild nausea shouldn’t stand in the way of healing from depression. With preparation, clear communication, and compassionate aftercare, most patients find Spravato® sessions increasingly comfortable and beneficial.
If you’re considering Spravato® therapy or need help managing side effects, our clinicians are here to guide you every step of the way — with expertise and empathy you can trust.
📞 Call today at (480) 758-4698 to schedule your free estimate!
