Treatment-Resistant Depression

Treatment-Resistant Depression services offered in Mesa, AZ

If you have severe depression that hasn’t responded to traditional treatments like medicines and talk therapy, turn to Blue Water Psychiatry in Mesa, Arizona. Board-certified psychiatric mental health nurse practitioners Justin McKinley, PMHNP-BC, Susan Bowen, PMHNP-BC, and their experienced staff offer expert solutions for treatment-resistant depression to help you through difficult emotions. Call the office or book an appointment online to learn more about treatment-resistant depression.

Treatment-Resistant Depression Q & A

FAQ

Treatment-resistant depression is a type of depression that hasn’t responded to psychotherapy and traditional depression medications (antidepressants). If you haven’t found relief from your symptoms with these treatment options, you may need other alternative approaches to lift your mood and improve your condition.

The common symptoms of treatment-resistant depression are the same as traditional depression.

These include: 

  • Appetite changes
  • Weight loss or weight gain
  • Ongoing despair, hopelessness, and worry 
  • Sleeping too little or having excessive sleep
  • Loss of interest in once-loved activities
  • Social isolation 

Treatment-resistant depression may affect your ability to perform well in school or at your job. At  Blue Water Psychiatry, the team offers a variety of depression treatments that may be able to help you get back on a path to success.

While treatment-resistant depression can happen to anyone, common risk factors include personal or family history of depression, traumatic or stressful life events, or having other mental health conditions – such as obsessive-compulsive disorder (OCD), anxiety, attention-deficit/hyperactivity disorder (ADHD) or attention deficit disorder (ADD), or post-traumatic stress disorder (PTSD).

You might feel depressed because of a career loss, financial issues, past traumatic experience, or relationship issues. However, it’s important to note that the relationship between depression and its cause may be unclear.

The Blue Water Psychiatry team can diagnose treatment-resistant depression after discussing your symptoms, current medication regimen, medical history, and lifestyle. They also ask questions about your thoughts and feelings in greater detail. 

Blue Water Psychiatry also offers pharmacogenomic testing to determine which medicines are likely the most effective based on your genes.

Blue Water Psychiatry offers traditional medications, psychotherapy, lifestyle-change counseling, and Spravato® nasal spray to reduce treatment-resistant depression symptoms. They tailor each treatment and update changes to your plan whenever necessary to help you get your life back on track.

To receive expert help for treatment-resistant depression, call Blue Water Psychiatry or book a consultation online today. The team also offers extended appointment times to ensure you get all the help you need. 

When Nothing Has Worked—We Offer What’s Next

If you’ve tried multiple medications or therapies with little to no relief, you may be experiencing treatment-resistant depression. We specialize in helping patients break through this wall using innovative, science-backed approaches.

Our Advanced Treatment Options

A New Hope for Relief

Just because past treatments haven’t worked doesn’t mean you’re out of options. At Blue Water Psychiatry, we’re committed to finding what works for you—with cutting-edge care designed for even the most complex cases of depression.

Our Satisfied Customers: See What They’re Saying

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Julia M. May 22, 2025
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5 Stars

Working with Justin has truly been life-changing. Justin is laid-back and immediately puts you at ease. He is very insightful and understands where you are coming from. Justin has taken great care with my medication management, works towards my goals, and has been the only provider in over 10 years to get amazing results on so few medications. I thank Justin for helping me get my life back! Thank you, Justin!

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Danny H. January 5, 2025
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5 Stars

Amazing practice. From our first meeting I felt like I'd known Justin for years! His office staff responds quickly to emails and phone calls and I'm always able to get in for an appointment as soon as I need one.

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Rachel S. November 22, 2024
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5 Stars

My son has been going to Justin for a couple years now and I couldn't imagine seeing anyone else! He is professional, attentive to our needs, and so kind! We are so thankful we found Justin!! Highly recommend him.

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Thomas W. March 3, 2025
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5 Stars

I thought Jolene took the time to hear my issues. She offered great insight. She took the time to evaluate the best medication options that might help through this difficult time. I would recommend her.

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Samantha L. February 18, 2025
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5 Stars

Jolene was AWESOME!!! She was very thorough and detailed; however, very informal and inviting. She made me feel welcome immediately; and, I truly felt she understood my questions. Her guidance was most definitely focused on my needs and concerns. I would absolutely recommend her to anyone who asked me my thoughts.

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Brenda C. January 30, 2025
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5 Stars

I have had nothing short of an amazing experience at Blue Water Psychiatry more specifically with Jolene. I am so thankful that I made the decision to ask for help. She listened to me and my situation and assessed my needs. In the past 6 months since first seeing Jolene I feel exponentially better than I did upon starting. Thankful for her direction and input. Absolutely recommend!

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Ashley B. August 2, 2024
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5 Stars

Jolene is fantastic! She's not just knowledgeable about medications, but she also creates a welcoming environment that puts patients at ease. Her caring approach truly makes a difference!

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Nico V. October 14, 2024
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5 Stars

I’ve seen Susan for almost a year now and my partner sees Justin. These providers have completely changed our lives, they are compassionate, knowledgeable and very thorough. They are VERY experienced and efficient, but never make you feel rushed... I will always recommend anyone in this wonderful practice. They are the best.

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Laura T. September 6, 2024
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5 Stars

It can be confusing, stressful, and a little unsettling when you’re looking into this type of care. I was pleasantly surprised to not feel one bit uncomfortable, and actually felt a sigh of relief from the very first visit and after leaving. I am so happy that we found her.

Services

ADD/ADHD
Anxiety
Depression
PTSD
Bipolar Disorder
Medication Management
OCD
Treatment Resistant Depression

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